Description

3-Methyl-5-(Trimethylsilyl)Isoxazole-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily needed by pharmaceutical R&D teams, agrochemical researchers, and advanced material scientists for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing functionalized isoxazole rings.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysts, and other specialty polymers.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & Contract Research: Essential for methodology development and complex molecule synthesis in university laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	3-Methyl-5-(Trimethylsilyl)Isoxazole-4-Boronic Acid Pinacol Ester
CAS No.	1429913-32-5
Molecular Formula	C14H26BNO3Si
Molecular Weight	295.26 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[3-methyl-5-(trimethylsilyl)isoxazol-4-yl]-1,3,2-dioxaborolane; 3-Methyl-5-(trimethylsilyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 3-Methyl-5-TMS-isoxazole-4-boronic acid pinacol ester; (3-Methyl-5-(trimethylsilyl)isoxazol-4-yl)boronic acid pinacol ester; Isoxazole-4-boronic acid pinacol ester, 3-methyl-5-(trimethylsilyl)-; Boronic acid, B-[3-methyl-5-(trimethylsilyl)-4-isoxazolyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(Trimethylsilyl)Isoxazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including NMR and HPLC, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.