Description

2,2,6,6-Tetramethyltetrahydro-2H-Pyran-4-Carboxylic Acid is a high-purity, sterically hindered carboxylic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique tetra-substituted pyran structure offers exceptional stability and controlled reactivity, making it invaluable for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty materials sectors who require precise and reliable intermediates for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where its hindered structure contributes to improved environmental stability and efficacy.
• Ligand and Catalyst Precursor: Serves as a precursor for sophisticated ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce sterically hindered, functional groups into polymer backbones to enhance thermal stability and material properties.
• Fine Chemical Production: A versatile intermediate in the multi-step synthesis of flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	2,2,6,6-Tetramethyltetrahydro-2H-Pyran-4-Carboxylic Acid
CAS No.	1429421-99-7
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	2,2,6,6-Tetramethyl-4-oxotetrahydropyran-4-carboxylic acid; 4-Carboxy-2,2,6,6-tetramethyltetrahydropyran; Tetramethyltetrahydropyran-4-carboxylic acid; 2,2,6,6-Tetramethyl-4-piperidone-4-carboxylic acid (tautomeric form); TMTHP-4-COOH; CAS 1429421-99-7
EINECS	Contact for details

Quality Control

Every batch of 2,2,6,6-Tetramethyltetrahydro-2H-Pyran-4-Carboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment to guarantee traceability and compliance with your procurement protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.