Description

2-Bromo-4,6-Difluoro-1,1'-Biphenyl is a high-purity, halogenated biphenyl derivative serving as a critical advanced pharmaceutical intermediate and versatile organic synthesis building block. Its unique structure, featuring bromine and fluorine substituents at specific positions, makes it an essential precursor for constructing complex molecules in medicinal chemistry and materials science. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the bioactivity of halogenated aromatic systems.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and liquid crystals, due to its conjugated biphenyl core.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.
• Academic & Contract Research: A valuable reagent for synthetic methodology research in universities and contract research organizations (CROs).

Basic Information

Product Name	2-Bromo-4,6-Difluoro-1,1'-Biphenyl
CAS No.	1428234-76-7
Molecular Formula	C12H7BrF2
Molecular Weight	269.09 g/mol
Synonyms	2-Bromo-4,6-difluorobiphenyl; [1,1'-Biphenyl]-2-bromo-4,6-difluoro; 4,6-Difluoro-2-bromobiphenyl; 2-Bromo-4,6-difluoro-1,1'-biphenyl; 2-Bromo-4,6-difluorodiphenyl; Biphenyl, 2-bromo-4,6-difluoro-; (2-Bromo-4,6-difluorophenyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,6-Difluoro-1,1'-Biphenyl is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.