Description

Cyclobutanecarboxylic Acid, 3-[[[(1,1-Dimethylethoxy)Carbonyl]Amino]Methyl]-, cis- is a high-purity, advanced pharmaceutical intermediate featuring a cis-substituted cyclobutane ring system. This compound matters for its role as a critical building block in the synthesis of complex, bioactive molecules, particularly in modern drug discovery programs. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Serves as a core structural component in the preparation of novel protease inhibitor candidates.
• Peptidomimetics: Used in constructing constrained peptide analogs to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.
• Chemical Biology Probes: Utilized in the development of tool compounds for target validation and mechanistic studies.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-[[[(1,1-Dimethylethoxy)Carbonyl]Amino]Methyl]-, cis-
CAS No.	1427319-48-9
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	cis-3-((((tert-Butoxy)carbonyl)amino)methyl)cyclobutanecarboxylic acid; (1s,3s)-3-(((tert-Butoxycarbonyl)amino)methyl)cyclobutanecarboxylic acid; Boc-ACBC-OH (cis isomer); cis-3-(Boc-aminomethyl)cyclobutanecarboxylic acid; (1s,3s)-3-((Boc-amino)methyl)cyclobutanecarboxylic acid; tert-Butyl ((cis-3-carboxycyclobutyl)methyl)carbamate; Cis-ACBC(Boc)-OH
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-[[[(1,1-Dimethylethoxy)Carbonyl]Amino]Methyl]-, cis- is produced under strict quality management systems to ensure batch-to-batch consistency for critical R&D and scale-up work. All batches are characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity, isomeric purity, and chemical purity. Certificates of Analysis (COA) detailing full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (cis-isomer)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.