Description

(3R,4R)-3-Fluorooxan-4-Amine is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of both fluorine and a stereodefined amine functional group, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Organofluorine Chemistry Research: Serves as a valuable substrate for studying novel fluorination reactions and for the preparation of specialized fluorinated compound libraries.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Peptidomimetic & Prodrug Design: The amine functionality makes it suitable for constructing fluorinated peptidomimetics or as a component in prodrug strategies.

Basic Information

Product Name	(3R,4R)-3-Fluorooxan-4-Amine
CAS No.	1422188-14-4
Molecular Formula	C5H10FNO
Molecular Weight	119.14 g/mol
Synonyms	(3R,4R)-3-Fluorotetrahydro-2H-pyran-4-amine; (3R,4R)-3-Fluoro-4-aminotetrahydropyran; 4-Amino-3-fluorotetrahydropyran, (3R,4R)-; (3R,4R)-3-Fluoro-4-aminotetrahydro-2H-pyran; (3R,4R)-3-Fluoro-4-aminodihydropyran; 3-Fluorooxan-4-amine, (3R,4R)-; (3R-cis)-3-Fluoro-4-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our (3R,4R)-3-Fluorooxan-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.