Description

Potassium Trifluoro(5-Methoxy-2-Pyridinyl)-Borate is a specialized organoboron reagent, specifically a potassium trifluoroborate salt, valued for its enhanced stability and handling properties compared to boronic acids. This compound serves as a crucial coupling partner in transition-metal catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional compounds. Its defined structure and consistent reactivity make it an essential building block for modern synthetic chemistry.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heteroaryl motifs prevalent in drug candidates.
• Agrochemical Research & Development: Used to create novel active ingredients and analogs for crop protection products.
• Material Science: Employed in the synthesis of organic electronic materials, ligands, and functional polymers.
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid generation of compound libraries for structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-up: Offers advantages in stability and purity for the development of robust, scalable manufacturing routes.
• Academic Research: A valuable tool for methodology development and complex molecule synthesis in university and institutional laboratories.

Basic Information

Product Name	Potassium Trifluoro(5-Methoxy-2-Pyridinyl)-Borate
CAS No.	1421347-21-8
Molecular Formula	C6H6BF3KNO
Molecular Weight	209.03 g/mol
Synonyms	Potassium (5-Methoxypyridin-2-yl)trifluoroborate; 5-Methoxy-2-pyridyltrifluoroborate Potassium Salt; Potassium 5-Methoxy-2-pyridyltrifluoroborate; (5-Methoxy-2-pyridinyl)trifluoroborate Potassium Salt; 2-(5-Methoxypyridyl)potassium trifluoroborate; Potassium Trifluoro(5-methoxy-2-pyridyl)borate; Potassium 5-Methoxy-2-pyridinyltrifluoroboronate
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(5-Methoxy-2-Pyridinyl)-Borate is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC for purity, and KF titration for moisture content, to ensure it meets the high standards required for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility Test	Soluble in common polar organic solvents (e.g., DMF, DMSO, MeOH)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.