Description

4,4-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride is a high-purity, fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in its unique molecular scaffold, which incorporates both a fluorinated pyran ring and a primary amine hydrochloride salt, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the difluorinated heterocycle can contribute to improved biological activity and environmental profile.
• Medicinal Chemistry & SAR Studies: Serves as a critical scaffold for structure-activity relationship (SAR) exploration, allowing chemists to rapidly generate analogs for biological screening.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes and tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in organic synthesis methodology and fluorine chemistry.

Basic Information

Product Name	4,4-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride
CAS No.	1418199-66-2
Molecular Formula	C5H10ClF2NO
Molecular Weight	173.59 g/mol
Synonyms	3-Amino-4,4-difluorotetrahydro-2H-pyran hydrochloride; 4,4-Difluoro-3-aminotetrahydropyran hydrochloride; 4,4-Difluorotetrahydro-2H-pyran-3-amine HCl; 3-Amino-4,4-difluorotetrahydropyran hydrochloride; 4,4-Difluoro-3-aminotetrahydropyran HCl; 4,4-Difluorotetrahydropyran-3-amine hydrochloride; 4,4-Difluoro-3-aminotetrahydropyran, hydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluorotetrahydro-2H-Pyran-3-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.