Description

(R)-4-(tert-Butoxycarbonyl)-6,6-Dimethylmorpholine-2-Carboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core value lies in its role as a key precursor for constructing complex, stereochemically defined molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained morpholine-based scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in catalytic asymmetric reactions to construct stereogenic centers.
• Agrochemical Research: Employed in the development of advanced, enantiomerically pure pesticides and herbicides.
• Ligand and Catalyst Development: Utilized for creating novel chiral ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A key building block for CDMOs (Contract Development and Manufacturing Organizations) producing custom APIs for clients.

Basic Information

Product Name	(R)-4-(tert-Butoxycarbonyl)-6,6-Dimethylmorpholine-2-Carboxylic Acid
CAS No.	1416445-02-7
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	(R)-6,6-Dimethylmorpholine-2,4-dicarboxylic acid 4-tert-butyl ester; (2R)-4-[(2-Methylpropan-2-yl)oxycarbonyl]-6,6-dimethylmorpholine-2-carboxylic acid; (R)-Boc-6,6-Dimethylmorpholine-2-carboxylic Acid; (R)-Boc-Dimethylmorpholine-2-Carboxylic Acid; tert-Butyl (R)-6,6-dimethyl-2-carboxymorpholine-4-carboxylate; (R)-4-Boc-6,6-dimethylmorpholine-2-carboxylic acid; (R)-Boc-DM-Mor-OH
EINECS	Contact for details

Quality Control

Our (R)-4-(tert-Butoxycarbonyl)-6,6-Dimethylmorpholine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.