Description

N,N''-[(1S,2S)-1,2-Diphenyl-1,2-Ethanediyl]Bis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea is a high-purity, chiral thiourea derivative of significant interest in advanced organic synthesis and catalysis. This compound matters as a sophisticated organocatalyst and ligand precursor, enabling highly selective chemical transformations critical for producing complex molecules. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for asymmetric synthesis, process development, and the creation of novel materials.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective reactions, such as Michael additions, Mannich reactions, and acylations.
• Ligand Synthesis: Serves as a key intermediate or precursor for constructing complex chiral ligands used in transition metal catalysis.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) requiring high stereochemical purity.
• Agrochemical Research: Applied in the synthesis of novel, chiral crop protection agents and herbicides.
• Material Science: Investigated for the development of chiral stationary phases (CSPs) for chromatography or advanced polymeric materials.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	N,N''-[(1S,2S)-1,2-Diphenyl-1,2-Ethanediyl]Bis[N'-[3,5-Bis(Trifluoromethyl)Phenyl]-Thiourea
CAS No.	1416334-72-9
Molecular Formula	C₃₂H₂₂F₁₂N₄S₂
Molecular Weight	786.66 g/mol
Synonyms	(1S,2S)-1,2-Diphenylethane-1,2-diyl bis(3-(3,5-bis(trifluoromethyl)phenyl)thiourea); (S,S)-1,2-Diphenyl-1,2-ethanediyl bis[N'-(3,5-bis(trifluoromethyl)phenyl)thiourea]; Chiral Bis(thiourea) Catalyst; Jacobsen Thiourea Analogue; (S,S)-TRIPHAT; Organocatalyst 1416334-72-9; Asymmetric Thiourea Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent content are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.