Description

2-Chloro-10,11-dihydrodibenzo[b,f]oxepin-10-ol is a structurally unique tricyclic phenolic compound featuring a chlorinated dibenzoxepin scaffold with a secondary alcohol functionality at the 10-position. It serves as a high-value synthetic intermediate in the development of novel central nervous system (CNS) modulators and selective receptor ligands due to its conformationally constrained aromatic-ether architecture and hydrogen-bonding capability. This compound is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in neuropharmacology, antipsychotic drug discovery, and GPCR-targeted medicinal chemistry programs.

Application

• Synthetic intermediate for next-generation tricyclic antidepressants and antipsychotics targeting serotonin and dopamine receptors
• Key building block in the preparation of selective 5-HT2A receptor antagonists for mood disorder therapeutics
• Chiral precursor in asymmetric synthesis of oxepin-based kinase inhibitors for oncology applications
• Structural motif in photoaffinity probes for mapping ligand-binding domains of CNS membrane proteins
• Research standard for metabolic stability assays (CYP450 inhibition, glucuronidation kinetics) in early ADMET profiling
• Reference material for method validation in LC-MS/MS bioanalysis of dibenzoxepin-class drug candidates
• Substrate in enzymatic studies of human alcohol dehydrogenase (ADH) and aldehyde oxidase (AOX) isoforms

Basic Information

Product Name	2-Chloro-10,11-dihydrodibenzo[b,f]oxepin-10-ol
CAS No.	1415559-87-3
Molecular Formula	C13H9ClO2
Molecular Weight	232.66 g/mol
Synonyms	2-Chloro-10-hydroxy-10,11-dihydrodibenzo[b,f]oxepin; 2-Chloro-10,11-dihydro-10-hydroxydibenzo[b,f]oxepin; 10-Hydroxy-2-chloro-10,11-dihydrodibenzo[b,f]oxepin; NSC 759223; DBX-10OH-Cl; 2-Chloro-10-ol-dibenzo[b,f]oxepin; 10-(Hydroxy)-2-chloro-10,11-dihydrodibenzo[b,f]oxepin; 2-Chloro-10-hydroxy-10,11-dihydrodibenzo[b,f]oxepine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), residual solvents (GC), heavy metals (ICP-MS), and water content (Karl Fischer). Testing adheres to ICH Q2(R2) guidelines and supports regulatory submissions under FDA, EMA, and PMDA frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to moisture and atmospheric oxygen; recommended under inert nitrogen atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	≤1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.