Description

6,7-Dihydro-2H-Pyrrolo[3,4-C]Pyridazin-3(5H)-One Hydrochloride is a high-purity, nitrogen-rich heterocyclic compound featuring a fused pyrrolopyridazine scaffold with a hydrochloride salt moiety. This molecule serves as a critical advanced intermediate in the synthesis of novel central nervous system (CNS) therapeutics and selective kinase inhibitors due to its structural resemblance to endogenous purine signaling motifs. It is primarily utilized by pharmaceutical R&D laboratories and contract development and manufacturing organizations (CDMOs) engaged in oncology, neuropharmacology, and inflammation drug discovery programs. Its hygroscopic nature demands stringent handling protocols to maintain integrity during storage and processing.

Application

• Key synthetic intermediate for preclinical candidates targeting PDE10A and GABAB receptor modulation
• Building block in structure–activity relationship (SAR) studies for next-generation antipsychotics and cognitive enhancers
• Core scaffold in medicinal chemistry libraries for high-throughput screening against neurological disease targets
• Starting material for the preparation of radiolabeled analogs (e.g., 11C or 18F derivatives) used in PET imaging probe development
• Substrate in asymmetric catalysis research for chiral heterocycle functionalization
• Reference standard in LC-MS/MS method validation for bioanalytical assay development

Basic Information

Product Name	6,7-Dihydro-2H-Pyrrolo[3,4-C]Pyridazin-3(5H)-One Hydrochloride
CAS No.	1415550-33-2
Molecular Formula	C7H8ClN3O
Molecular Weight	185.61 g/mol
Synonyms	6,7-Dihydro-2H-pyrrolo[3,4-c]pyridazin-3(5H)-one hydrochloride; 3-Oxo-2,3,5,6,7,8-hexahydropyrrolo[3,4-c]pyridazine hydrochloride; RP-1415550-33-2; PYRROLOPYRIDAZINONE HCl; 6,7-Dihydro-3H-pyrrolo[3,4-c]pyridazin-3-one hydrochloride; NSC 1415550-33-2; ML-1415550-33-2; TCI-1415550-33-2
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to strict internal specifications aligned with ICH Q5, Q7, and ISO 9001:2015 requirements. Testing includes identity confirmation (IR, 1H-NMR), assay (HPLC), residual solvent analysis (GC), heavy metals (ICP-MS), and water content (Karl Fischer). Available grades include Research Grade (≥98.0%) and GMP-intermediate Grade (≥99.5%).

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under dry, inert conditions. Due to its hygroscopic nature, minimize exposure to ambient humidity and handle only in a controlled environment with desiccated glove boxes or nitrogen-purged vessels.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (1H-NMR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	≤1.5% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.