Description

3-Amino-5-Trifluoromethyl-Pyridine Hydrochloride is a high-purity, halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the unique combination of a reactive amino group and a stable, electron-withdrawing trifluoromethyl group, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine scaffold.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functional polymers, liquid crystals, and electronic materials where fluorine incorporation modifies physical properties.
• Chemical Biology & Proteomics: Used as a labeling reagent or a building block for activity-based probes and molecular tags.

Basic Information

Product Name	3-Amino-5-Trifluoromethyl-Pyridine Hydrochloride
CAS No.	1414958-36-3
Molecular Formula	C7H6ClF3N2
Molecular Weight	210.58 g/mol
Synonyms	5-(Trifluoromethyl)pyridine-3-amine hydrochloride; 3-Amino-5-(trifluoromethyl)pyridine HCl; 3-Pyridinamine, 5-(trifluoromethyl)-, hydrochloride (1:1); 5-(Trifluoromethyl)-3-pyridinamine hydrochloride; 3-Amino-5-trifluoromethylpyridine monohydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Trifluoromethyl-Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.