Description

(2E)-Tco-Oh CAS NO 1414375-00-0 is a high-purity, specialized chemical intermediate featuring a trans-cyclooctene (TCO) moiety. This compound is critical for enabling rapid, bioorthogonal click chemistry reactions, particularly inverse electron demand Diels-Alder (IEDDA) cycloadditions with tetrazines. It is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require efficient, selective, and traceless linking strategies for labeling biomolecules, developing antibody-drug conjugates (ADCs), and creating advanced diagnostic probes.

Application

• Bioconjugation & ADC Development: Site-specific labeling of antibodies, proteins, and peptides for the creation of targeted therapeutics.
• Pre-targeting Strategies: A key component in multi-step radiopharmaceutical and imaging agent pre-targeting systems.
• Chemical Biology & Proteomics: Tool for live-cell imaging, surface engineering, and studying biomolecular interactions via fast click chemistry.
• Polymer & Material Science: Functionalization of surfaces, nanoparticles, and hydrogels with bioactive ligands.
• Diagnostic Probe Synthesis: Construction of fluorescent, radioactive, or magnetic imaging agents for in vitro and in vivo diagnostics.
• Linker Technology: Serves as a reactive handle for constructing cleavable or non-cleavable linkers in prodrugs and drug delivery systems.

Basic Information

Product Name	(2E)-Tco-Oh
CAS No.	1414375-00-0
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	(2E)-trans-Cyclooct-2-en-1-ol; trans-Cyclooct-2-enol; TCO-OH; (E)-Cyclooct-2-en-1-ol; 2E-TCO alcohol; BCN-OH (related); DBCO precursor; Bioorthogonal click chemistry reagent
EINECS	Contact for details

Quality Control

Every batch of (2E)-Tco-Oh is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports compliance in research and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store the product at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate at -20°C. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isomeric Purity ((2E)-isomer)	≥ 98%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.