Description

Potassium (Tetrahydro-2H-Pyran-2-Yl)Methyltrifluoroborate is a versatile organotrifluoroborate salt, a crucial class of reagents prized for their stability and reactivity in cross-coupling reactions. This compound serves as a valuable synthetic building block, enabling the efficient and selective introduction of complex alkyl fragments into target molecules. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of new active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable, air- and moisture-tolerant alkyl boronic acid equivalent for coupling with aryl/heteroaryl halides.
• Pharmaceutical Intermediate Synthesis: Used in the construction of complex drug candidates, particularly those requiring chiral or sterically hindered alkyl groups.
• Agrochemical Product Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides with tailored properties.
• Material Science Research: Facilitates the creation of functional organic molecules for applications in organic electronics and polymer chemistry.
• Process Chemistry & Scale-up: Its improved handling characteristics compared to boronic acids make it suitable for optimizing and scaling synthetic routes.
• Academic & R&D Laboratories: A key reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	Potassium (Tetrahydro-2H-Pyran-2-Yl)Methyltrifluoroborate
CAS No.	1408168-78-4
Molecular Formula	C7H13BF3KO
Molecular Weight	220.09 g/mol
Synonyms	Potassium (Tetrahydro-2H-pyran-2-yl)methyltrifluoroborate; Potassium [(Tetrahydro-2H-pyran-2-yl)methyl]trifluoroborate; (Tetrahydro-2H-pyran-2-yl)methyltrifluoroborate Potassium Salt; THP-Methyl-Trifluoroborate Potassium Salt; 2-((Trifluoroboranyl)methyl)tetrahydro-2H-pyran Potassium Salt
EINECS	Contact for details

Quality Control

Our Potassium (Tetrahydro-2H-Pyran-2-Yl)Methyltrifluoroborate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (NMR), purity (HPLC), and identity confirmation. Our quality system is designed to meet the rigorous standards required for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) and protected from moisture. Recommended long-term storage at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Conforms to structure
Assay (NMR)	≥95%
Purity (HPLC)	≥97%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.