Description

cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanol CAS NO 1408074-89-4 is a high-purity, protected cyclobutanol derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecular architectures in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the cyclobutane moiety, a valuable scaffold in medicinal chemistry for conformational restriction.
• Process Chemistry: Serves as a protected alcohol precursor in multi-step kilogram-scale manufacturing processes under GMP conditions.
• Academic & Industrial Research: Employed in methodological development and the construction of complex natural product analogs and bioactive molecules.
• Ligand and Catalyst Development: Potential precursor for chiral ligands or organocatalysts used in enantioselective transformations.

Basic Information

Product Name	cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanol
CAS No.	1408074-89-4
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	cis-3-((tert-Butyldimethylsilyl)oxy)cyclobutanol; (1r,3s)-3-((tert-Butyldimethylsilyl)oxy)cyclobutanol; cis-3-(TBDMS-oxy)cyclobutanol; 3-[(tert-Butyldimethylsilyl)oxy]cyclobutanol (cis-); TBDMS ether of cis-3-cyclobutanol; Cyclobutanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, cis-; 1408074-89-4; cis-3-O-TBDMS-cyclobutanol
EINECS	Contact for details

Quality Control

Our cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) with full traceability are provided, supporting development under ISO and cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.