Description

4-Methoxy-2-(Trifluoromethyl)Benzamidine Hydrochloride is a high-purity benzamidine derivative, a key building block in modern organic synthesis. Its value lies in its trifluoromethyl and methoxy functional groups, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of protease inhibitors and other bioactive compounds. The CAS number for this material is 1408058-12-7.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially protease inhibitors and enzyme-targeted therapies.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances metabolic stability and bioactivity.
• Chemical Biology Probe: Serves as a key precursor for creating activity-based probes to study enzyme function and mechanism.
• Organic Synthesis Reagent: Employed in medicinal chemistry for introducing the benzamidine pharmacophore into complex molecular architectures.
• Bioconjugation & Linker Chemistry: Utilized in the preparation of specialized linkers for antibody-drug conjugates (ADCs) and other targeted delivery systems.

Basic Information

Product Name	4-Methoxy-2-(Trifluoromethyl)Benzamidine Hydrochloride
CAS No.	1408058-12-7
Molecular Formula	C9H10F3N2O·HCl
Molecular Weight	254.64 g/mol
Synonyms	4-Methoxy-2-(trifluoromethyl)benzenecarboximidamide hydrochloride; 2-Trifluoromethyl-4-methoxybenzamidine HCl; 4-Methoxy-α,α,α-trifluoro-o-toluidine hydrochloride; Benzamidine, 4-methoxy-2-(trifluoromethyl)-, hydrochloride; 1408058-12-7; 4-Methoxy-2-trifluoromethylbenzamidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-(Trifluoromethyl)Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.