Description

5,8,11,14-Tetraoxa-2-Azahexadecanoic Acid, 16-[[(4-Methylphenyl)Sulfonyl]Oxy]-, 1,1-Dimethylethyl Ester is a specialized, high-purity chemical intermediate featuring a unique polyether-azacarboxylic acid structure protected by a tert-butyl ester and activated with a tosylate leaving group. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the controlled introduction of functionalized polyether chains. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring polyethylene glycol (PEG)-like linkers or solubilizing chains.
• Prodrug Synthesis: Utilized in constructing prodrug molecules where the tosylate group facilitates conjugation to drug molecules for targeted release.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored hydrophilicity, biodegradability, or self-assembly properties.
• Bioconjugation & Linker Chemistry: Employed in attaching drugs, dyes, or other molecules to proteins, antibodies, or nanoparticles via its reactive ester and sulfonate groups.
• Agrochemical Research: Used in the development of new herbicides, pesticides, or plant growth regulators that benefit from polyether-modified structures.
• Surface Modification: Applied to modify material surfaces to enhance biocompatibility, lubrication, or specific chemical functionality.

Basic Information

Product Name	5,8,11,14-Tetraoxa-2-Azahexadecanoic Acid, 16-[[(4-Methylphenyl)Sulfonyl]Oxy]-, 1,1-Dimethylethyl Ester
CAS No.	1404111-69-8
Molecular Formula	C24H39NO9S
Molecular Weight	517.63 g/mol
Synonyms	tert-Butyl 16-((p-tolylsulfonyl)oxy)-5,8,11,14-tetraoxa-2-azahexadecanoate; 2-[2-[2-[2-[2-(tert-Butoxy)-2-oxoethoxy]ethoxy]ethoxy]ethoxy]-N-(4-methylphenylsulfonyloxyethyl)acetamide; PEG4 Tosylate tert-Butyl Ester Carboxylic Acid Derivative; 16-[(4-Methylbenzenesulfonyl)oxy]-5,8,11,14-tetraoxa-2-azahexadecanoic acid tert-butyl ester; Tetraethylene glycol derivative tosylate tert-butyl ester; Boc-PEG4-OTs (related analog); Contact for details for additional trade names.
EINECS	Contact for details

Quality Control

Our 5,8,11,14-Tetraoxa-2-Azahexadecanoic Acid, 16-[[(4-Methylphenyl)Sulfonyl]Oxy]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity (IR, NMR), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical grade, higher purity available)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.