Description

1-Bromo-4-Chloro-2-(Trifluoromethoxy)Benzene is a high-value, multi-functional halogenated aromatic building block designed for advanced chemical synthesis. Its unique structure, featuring bromine, chlorine, and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, leveraging the reactive bromine site for selective bond formation.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D for constructing complex, fluorinated aromatic scaffolds in medicinal and synthetic chemistry programs.

Basic Information

Product Name	1-Bromo-4-Chloro-2-(Trifluoromethoxy)Benzene
CAS No.	1402672-86-9
Molecular Formula	C7H3BrClF3O
Molecular Weight	275.45 g/mol
Synonyms	4-Bromo-1-Chloro-2-(Trifluoromethoxy)Benzene; 2-Bromo-5-Chloro-1-(Trifluoromethoxy)Benzene; 1-Chloro-4-Bromo-2-(Trifluoromethoxy)Benzene; Benzene, 1-bromo-4-chloro-2-(trifluoromethoxy)-; 2-Trifluoromethoxy-4-bromochlorobenzene; 4-Bromo-2-(trifluoromethoxy)chlorobenzene; BCTFB (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-Chloro-2-(Trifluoromethoxy)Benzene is manufactured and tested under a strict quality management system to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.