Description

Ethyl cis-4-Aminotetrahydro-2H-Pyran-3-Carboxylate Hcl is a high-purity pharmaceutical intermediate and chiral building block of significant synthetic value. This compound is essential for research and development in medicinal chemistry, particularly for constructing complex molecules with defined stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• API Synthesis: Used as a critical building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a cis-substituted tetrahydropyran scaffold.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of novel chemical space in drug discovery programs.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in asymmetric synthesis routes due to its defined stereochemistry.
• Fine Chemical Production: Employed in the manufacture of specialty and custom fine chemicals for advanced research applications.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for client-specific synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Ethyl cis-4-Aminotetrahydro-2H-Pyran-3-Carboxylate Hydrochloride
CAS No.	1398503-99-5
Molecular Formula	C8H16ClNO3
Molecular Weight	209.67 g/mol
Synonyms	Ethyl cis-4-Aminotetrahydro-2H-pyran-3-carboxylate hydrochloride; cis-Ethyl 4-aminooxane-3-carboxylate hydrochloride; 4-Amino-tetrahydro-2H-pyran-3-carboxylic acid ethyl ester hydrochloride; Ethyl 4-aminotetrahydropyran-3-carboxylate HCl; 3-Carbethoxy-4-aminotetrahydropyran hydrochloride (cis isomer); (3R,4S)- and/or (3S,4R)-Ethyl 4-aminooxane-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl cis-4-Aminotetrahydro-2H-Pyran-3-Carboxylate Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.