Description

4-Amino-Tetrahydro-Furan-3-Carboxylic Acid is a high-value, non-proteinogenic amino acid derivative featuring a unique tetrahydrofuran scaffold. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical and biotechnology research organizations for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic diseases.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing stability, bioavailability, and target selectivity.
• Chemical Biology & Proteomics: Serves as a specialized probe or building block for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst ligand in stereoselective organic transformations.
• Agrochemical Research: Investigated for the development of novel, biologically active compounds with specific modes of action.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and discovery chemistry projects.

Basic Information

Product Name	4-Amino-Tetrahydro-Furan-3-Carboxylic Acid
CAS No.	1396972-35-2
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	4-Aminotetrahydrofuran-3-carboxylic acid; (3R,4S)-4-Aminotetrahydrofuran-3-carboxylic acid; (3S,4R)-4-Aminotetrahydrofuran-3-carboxylic acid; 3-Carboxy-4-aminotetrahydrofuran; 4-Amino-3-furancarboxylic acid, tetrahydro-; 4-Aminotetrahydro-3-furancarboxylic acid; ATFC; Furan-3-carboxylic acid, 4-amino-tetrahydro-
EINECS	Contact for details

Quality Control

Our 4-Amino-Tetrahydro-Furan-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer-specific grades available)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.