Description

Oxetan-3-Ylmethyl 4-Methylbenzenesulfonate is a high-value sulfonate ester derivative, specifically functionalized with an oxetane ring, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile alkylating agent and a key intermediate for introducing the oxetane moiety, a privileged scaffold known for improving the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those incorporating the metabolically stable oxetane ring to modulate solubility, potency, and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the oxetane group can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of novel polymers with specific thermal or mechanical properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes to study biological systems.
• Ligand and Catalyst Development: Useful intermediate for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under GMP or non-GMP conditions.

Basic Information

Product Name	Oxetan-3-Ylmethyl 4-Methylbenzenesulfonate
CAS No.	1395417-57-8
Molecular Formula	C11H14O4S
Molecular Weight	242.29 g/mol
Synonyms	Oxetan-3-ylmethyl tosylate; 3-(Tosyloxymethyl)oxetane; (Oxetan-3-yl)methyl 4-methylbenzenesulfonate; p-Toluenesulfonic acid oxetan-3-ylmethyl ester; Tosyloxymethyloxetane; Oxetane-3-methyl tosylate; 1395417-57-8; 4-Methylbenzenesulfonic acid oxetan-3-ylmethyl ester
EINECS	Contact for details

Quality Control

Our Oxetan-3-Ylmethyl 4-Methylbenzenesulfonate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and commercial synthesis. Each batch is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development projects requiring material that meets in-house specifications or aligns with ICH guidelines for impurity identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.