Description

(3S,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine is a high-value, chiral fluorinated building block essential for modern pharmaceutical and agrochemical research. Its unique stereochemistry and fluorine substitution make it a critical intermediate for developing novel active ingredients with enhanced metabolic stability and bioavailability. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical industry for applications in medicinal chemistry and as a key synthon in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships (SAR) by introducing a fluorine atom at a specific stereocenter, a common strategy in lead optimization.
• Asymmetric Synthesis: Serves as a valuable chiral amine precursor or scaffold for constructing complex, enantiomerically pure molecules.
• Agrochemical Research: Employed in the development of new pesticides and herbicides where the fluorinated pyran structure can contribute to biological activity.
• Ligand and Catalyst Development: Can be utilized to synthesize novel chiral ligands or organocatalysts for asymmetric transformations.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological mechanisms and enzyme interactions.

Basic Information

Product Name	(3S,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine
CAS No.	1395080-73-5
Molecular Formula	C5H10FNO
Molecular Weight	119.14 g/mol
Synonyms	(3S,4S)-3-Fluorooxan-4-amine; (3S,4S)-3-Fluorotetrahydro-2H-pyran-4-amine; 4-Amino-3-fluorotetrahydropyran, (3S,4S)-; 3-Fluoro-tetrahydro-pyran-4-ylamine, (3S,4S)-; (3S,4S)-3-Fluoro-4-aminotetrahydropyran; (3S,4S)-3-Fluoro-4-aminotetrahydro-2H-pyran; (3S,4S)-3-Fluoro-4-aminotetrahydro-2H-pyran; (3S,4S)-3-Fluoro-4-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our (3S,4S)-3-Fluorotetrahydro-2H-Pyran-4-Amine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, critical for sensitive R&D applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), chiral purity (by chiral HPLC), and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.