Description

3-Ethynyltetrahydro-2H-Pyran-3-Ol is a high-value, functionalized heterocyclic building block featuring both an ethynyl group and a tertiary alcohol within a tetrahydropyran scaffold. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in fragment-based drug discovery and for introducing alkyne handles for click chemistry.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators that require specific stereochemistry and functional group compatibility.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the synthesis of complex chelating ligands and organocatalysts due to its oxygen-rich and modifiable structure.
• Chemical Biology Probes: Utilized to create molecular probes and tags for studying biological systems, leveraging the reactive alkyne group for bio-conjugation.
• Academic & Contract Research: Essential reagent for synthetic organic chemistry research in universities and contract research organizations (CROs).

Basic Information

Product Name	3-Ethynyltetrahydro-2H-Pyran-3-Ol
CAS No.	1394119-79-9
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	3-Ethynyloxan-3-ol; 3-Ethynyltetrahydro-2H-pyran-3-ol; 3-Hydroxy-3-ethynyltetrahydropyran; 3-Ethynyl-3-hydroxytetrahydropyran; THP-protected propargylic alcohol; 3-Ethynyl-3-hydroxyoxane
EINECS	Contact for details

Quality Control

We supply 3-Ethynyltetrahydro-2H-Pyran-3-Ol in high-purity grades suitable for research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. We adhere to cGMP and ISO 9001 principles in our manufacturing and quality management processes to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.