Description

Lithium (6-Methoxypyridin-2-Yl)Trihydroxyborate is a specialized organoboron reagent, specifically a lithium borate complex, used as a key intermediate in advanced organic synthesis. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura coupling, which is critical for constructing complex pharmaceutical and agrochemical molecules. This high-purity compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality building blocks for creating novel compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-aryl bond formations.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors, where controlled coupling is necessary.
• Suzuki-Miyaura Cross-Coupling Reactions: Functions as a stable, air- and moisture-sensitive boronic acid equivalent, offering advantages in handling and reactivity for forming carbon-carbon bonds.
• Chemical Library Development: Employed in medicinal chemistry for the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Used in the synthesis of complex organic ligands and catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Lithium (6-Methoxypyridin-2-Yl)Trihydroxyborate
CAS No.	1393822-93-9
Molecular Formula	C6H7BLiNO4
Molecular Weight	166.89 g/mol
Synonyms	Lithium (6-Methoxypyridin-2-yl)borate(1-); 6-Methoxy-2-pyridinylboronic acid lithium salt; 2-(6-Methoxypyridinyl)boronic acid lithium salt; Lithium 6-methoxypyridin-2-yltrihydroborate; (6-Methoxy-2-pyridinyl)boronic acid lithium complex; Borate(1-), (6-methoxy-2-pyridinyl)trihydro-, lithium; Lithium (6-methoxypyridin-2-yl)trihydroxyborate; 2-Pyridineboronic acid, 6-methoxy-, lithium salt (1:1)
EINECS	Contact for details

Quality Control

Our Lithium (6-Methoxypyridin-2-Yl)Trihydroxyborate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP for pharmaceutical intermediates and aligns with ISO 9001 quality management principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. For long-term storage, consider storing under an inert gas in a sealed container with desiccant.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0%
Purity (NMR)	Conforms
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.