Description

Lithium (6-(Trifluoromethyl)Pyridin-2-Yl)Trihydroxyborate is a specialized organoboron reagent, specifically a lithium trifluoroborate salt, with the CAS number 1393822-87-1. This compound is a valuable building block in modern synthetic chemistry, prized for its enhanced stability and reactivity compared to traditional boronic acids. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use in key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, enabling the efficient synthesis of complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing biaryl and heterobiaryl motifs prevalent in active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Research & Development: Used in the discovery and synthesis of novel crop protection agents and herbicides that incorporate the trifluoromethylpyridine scaffold.
• Material Science Precursor: Serves as a building block for creating advanced organic electronic materials and liquid crystals.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for screening new drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Fine Chemical Manufacturing: Employed in the scalable production of complex, high-value specialty chemicals and flavors & fragrances.

Basic Information

Product Name	Lithium (6-(Trifluoromethyl)Pyridin-2-Yl)Trihydroxyborate
CAS No.	1393822-87-1
Molecular Formula	C6H4BF3LiNO3
Molecular Weight	200.86 g/mol
Synonyms	Lithium (6-(Trifluoromethyl)-2-pyridyl)trifluoroborate; 2-(Trifluoromethyl)pyridine-6-trifluoroboronic acid lithium salt; (6-(Trifluoromethyl)pyridin-2-yl)trifluoroboronic acid lithium salt; 2-Pyridineboronic acid, 6-(trifluoromethyl)-, trifluoroborate lithium complex; Lithium trifluoro[6-(trifluoromethyl)-2-pyridyl]borate; (6-(Trifluoromethyl)-2-pyridinyl)trifluoroboronic acid lithium salt; Lithium (6-(trifluoromethyl)-2-pyridyl)trifluoroborate; Potassium (6-(Trifluoromethyl)pyridin-2-yl)trifluoroborate (common analogue)
EINECS	Contact for details

Quality Control

Our production of Lithium (6-(Trifluoromethyl)Pyridin-2-Yl)Trihydroxyborate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B) for structural confirmation and HPLC for purity assessment. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, water content (KF), and residual solvent levels to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, store at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
NMR Assay (¹H)	≥90%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.