Description

Lithium (5-(Trifluoromethyl)pyridin-2-yl)trihydroxyborate is a specialized organoboron reagent, specifically a lithium trifluoroborate salt, used as a key building block in modern synthetic chemistry. Its value lies in its enhanced stability and reactivity compared to traditional boronic acids, making it a superior choice for critical cross-coupling reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A stable and effective precursor for introducing the 5-(trifluoromethyl)pyridin-2-yl moiety into biaryl and heterobiaryl systems, crucial for drug discovery.
• Pharmaceutical Intermediate Synthesis: Serves as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Product Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the trifluoromethylpyridine group imparts desirable biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Employed in the creation of specialized ligands for catalysis and as a component in metal-organic frameworks (MOFs) or functional materials.
• Chemical Biology & Medicinal Chemistry: Facilitates the synthesis of probe molecules and labeled compounds for biological target identification and validation studies.
• Process Chemistry & Scale-Up: Offers advantages in handling and purification for the large-scale manufacturing of fine chemicals and advanced intermediates.

Basic Information

Product Name	Lithium (5-(Trifluoromethyl)pyridin-2-yl)trihydroxyborate
CAS No.	1393822-86-0
Molecular Formula	C6H4BF3LiNO3
Molecular Weight	200.86 g/mol
Synonyms	Lithium [5-(Trifluoromethyl)-2-pyridyl]trifluoroborate; (5-(Trifluoromethyl)pyridin-2-yl)trifluoroborate lithium salt; 2-(5-Trifluoromethyl-2-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (common precursor); 5-(Trifluoromethyl)-2-pyridineboronic acid, trifluoroborate lithium complex; 2-Pyridineboronic acid, 5-(trifluoromethyl)-, lithium trifluoroborate adduct; Lithium (5-Trifluoromethyl-2-pyridyl)trifluoroborate.
EINECS	Contact for details

Quality Control

Every batch of Lithium (5-(Trifluoromethyl)pyridin-2-yl)trihydroxyborate is manufactured and tested under a strict quality management system. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including NMR (1H, 13C, 19F, 11B), HPLC, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤2.0%
NMR Purity (1H, 19F)	≥95%
Elemental Analysis	Conforms to theoretical values (±0.4%)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.