Description

Lithium (3-Fluoropyridin-2-Yl)Triisopropoxyborate is a specialized organoboron reagent, specifically a lithium triisopropoxy(heteroaryl)borate salt, designed for advanced synthetic transformations. This compound is a valuable building block in modern pharmaceutical and agrochemical research, enabling the precise introduction of the 3-fluoropyridin-2-yl moiety into complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronate source for coupling with aryl/heteroaryl halides to construct biaryl systems containing fluorinated pyridine rings.
• Pharmaceutical Intermediate Synthesis: A key precursor in the development of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluoropyridine unit enhances biological activity and metabolic stability.
• Material Science & OLED Development: Employed in the creation of electron-transport materials and ligands for metal-organic frameworks (MOFs) due to its electron-deficient heterocyclic structure.
• Process Chemistry & Scale-up: Offers advantages in manufacturing processes due to its improved handling characteristics compared to some sensitive boronic acids.

Basic Information

Product Name	Lithium (3-Fluoropyridin-2-Yl)Triisopropoxyborate
CAS No.	1393822-82-6
Molecular Formula	C14H22BF1LiNO3
Molecular Weight	281.09 g/mol
Synonyms	Lithium Triisopropoxy(3-fluoropyridin-2-yl)borate; 3-Fluoropyridin-2-yltriisopropoxyborate Lithium Salt; (3-Fluoropyridin-2-yl)triisopropoxyboron Lithium Complex; 2-(3-Fluoropyridinyl)triisopropoxyborate Lithium; Lithium (3-Fluoro-2-pyridyl)triisopropoxyborate; Borate(1-), triisopropoxy(3-fluoro-2-pyridinyl)-, lithium; Lithium (3-Fluoropyridin-2-yl)triisopropoxyborohydride (common misnomer)
EINECS	Contact for details

Quality Control

Our Lithium (3-Fluoropyridin-2-Yl)Triisopropoxyborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 11B, 19F) and HPLC analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen). Due to its hygroscopic (moisture-sensitive) nature, the container must be opened and handled in a controlled, dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.