Description

Morpholine, 3-(Difluoromethyl)- is a specialized heterocyclic building block featuring a difluoromethyl substituent on the morpholine ring. This compound is valued for its unique chemical structure, which combines the polarity and basicity of morpholine with the lipophilicity and metabolic stability imparted by the fluorine atoms. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors, enabling the synthesis of novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine into bioactive molecules to improve metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethyl-morpholine moiety can contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in organometallic chemistry and catalysis as a building block for creating novel nitrogen-containing ligands.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	Morpholine, 3-(Difluoromethyl)-
CAS No.	1393554-05-6
Molecular Formula	C5H9F2NO
Molecular Weight	137.13 g/mol
Synonyms	3-(Difluoromethyl)morpholine; 3-Difluoromethylmorpholine; 4-Morpholinepropanamine, 3,3-difluoro-; 3,3-Difluoro-4-morpholinepropanamine; Morpholine, 3-(difluoromethyl)-; 1393554-05-6
EINECS	Contact for details

Quality Control

Our Morpholine, 3-(Difluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.