Description

(3R,4As,10Br)-4A,5,6,10B-Tetrahydro-3-(4-Hydroxy-3-Methoxyphenyl)-9-Methoxy-3H-Naphtho[2,1-B]Pyran-8-Ol is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key chiral building block in the synthesis of novel therapeutic agents, particularly within the fields of oncology and neurology. It is primarily needed by R&D chemists, process development scientists, and manufacturers in the pharmaceutical and biotechnology industries who require reliable access to structurally defined, high-quality intermediates for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization, particularly for complex polycyclic targets.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of candidate drugs, leveraging its defined stereochemistry.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in API manufacturing.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays to study enzyme inhibition or receptor binding.
• Custom Synthesis: A starting point for the custom synthesis of more complex, proprietary molecules for specialized client projects.

Basic Information

Product Name	(3R,4As,10Br)-4A,5,6,10B-Tetrahydro-3-(4-Hydroxy-3-Methoxyphenyl)-9-Methoxy-3H-Naphtho[2,1-B]Pyran-8-Ol
CAS No.	1392476-32-2
Molecular Formula	C21H21BrO5
Molecular Weight	433.30 g/mol
Synonyms	1392476-32-2; 3H-Naphtho[2,1-b]pyran-8-ol, 4a,5,6,10b-tetrahydro-3-(4-hydroxy-3-methoxyphenyl)-9-methoxy-, (3R,4aR,10bR)-; (3R,4aR,10bR)-4a,5,6,10b-Tetrahydro-3-(4-hydroxy-3-methoxyphenyl)-9-methoxy-3H-naphtho[2,1-b]pyran-8-ol; Brominated Tetrahydro Naphthopyranol Derivative; Chiral Bromo-Naphthopyran Intermediate
EINECS	Contact for details

Quality Control

Our (3R,4As,10Br)-4A,5,6,10B-Tetrahydro-3-(4-Hydroxy-3-Methoxyphenyl)-9-Methoxy-3H-Naphtho[2,1-B]Pyran-8-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for demanding research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.