Description

(4S)-8-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those working on central nervous system (CNS) and cardiovascular drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex drug molecules, particularly those containing a benzopyran scaffold.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically pure compounds due to its defined (4S) stereocenter.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Biochemical Research: Employed in the study of enzyme inhibitors and receptor ligands.

Basic Information

Product Name	(4S)-8-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride
CAS No.	1392219-01-0
Molecular Formula	C9H11ClFNO
Molecular Weight	203.64 g/mol
Synonyms	(4S)-8-Fluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (4S)-8-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine HCl; 8-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride, (4S)-; (S)-8-Fluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; 1392219-01-0; 4-Amino-8-fluoro-3,4-dihydro-2H-chromene hydrochloride, (4S)-
EINECS	Contact for details

Quality Control

Our (4S)-8-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.