Description

5,7-Difluorochroman-4-Amine Hydrochloride is a high-purity fluorinated chiral building block and pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry where the introduction of fluorine atoms can significantly alter biological activity and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where enhanced efficacy and environmental profile are required.
• Chemical Research: Serves as a versatile building block in organic synthesis for constructing complex chroman and fluorine-containing heterocyclic structures.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production for new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	5,7-Difluorochroman-4-Amine Hydrochloride
CAS No.	1392211-80-1
Molecular Formula	C9H10ClF2NO
Molecular Weight	221.63 g/mol
Synonyms	4-Amino-5,7-difluorochroman hydrochloride; 5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; 5,7-Difluorochroman-4-amine HCl; 4-Chromanamine, 5,7-difluoro-, hydrochloride; 1392211-80-1; 5,7-Difluoro-4-chromanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 5,7-Difluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.