Description

4-(tert-Butoxycarbonylamino)Tetrahydrofuran-3-Yl Methanesulfonate is a high-purity, protected amino acid derivative and a key chiral building block in advanced organic synthesis. This compound is essential for the efficient and stereoselective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and other small molecule drug discovery programs.
• Peptidomimetic Synthesis: Used to introduce protected amino-tetrahydrofuran motifs into peptide backbones, creating stable peptidomimetics with enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for the synthesis of advanced chiral herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates under cGMP conditions.
• Academic & Institutional Research: Used in university and institutional laboratories for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	4-(tert-Butoxycarbonylamino)Tetrahydrofuran-3-Yl Methanesulfonate
CAS No.	1391732-77-6
Molecular Formula	C11H21NO6S
Molecular Weight	295.35 g/mol
Synonyms	Boc-3-Amino-tetrahydrofuran-4-yl Mesylate; (3R,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]tetrahydro-3-furanyl Methanesulfonate; 4-[(tert-Butoxycarbonyl)amino]tetrahydrofuran-3-yl Methanesulfonate; 4-(Boc-amino)tetrahydrofuran-3-yl Mesylate; 3-Amino-4-hydroxy-tetrahydrofuran, N-Boc protected, 4-mesylate; 1391732-77-6; tert-Butyl N-[(3R,4S)-4-(methylsulfonyloxy)oxolan-3-yl]carbamate
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxycarbonylamino)Tetrahydrofuran-3-Yl Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.