Description

3-(4-Chlorophenyl)Cyclobutane-1-Carboxylic Acid is a high-purity, synthetically versatile cyclobutane derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a carboxylic acid group and a chlorinated aromatic ring on a strained cyclobutane core, makes it an invaluable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the chlorophenyl and carboxylic acid functionalities contribute to biological activity.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystals, where the rigid cyclobutane ring enhances thermal and mechanical properties.
• Chemical Biology Probe: Utilized as a core structure for developing molecular probes to study enzyme function and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP conditions for clinical trial material production.

Basic Information

Product Name	3-(4-Chlorophenyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1384429-60-0
Molecular Formula	C11H11ClO2
Molecular Weight	210.66 g/mol
Synonyms	3-(4-Chlorophenyl)cyclobutane-1-carboxylic acid; 3-(p-Chlorophenyl)cyclobutanecarboxylic acid; 4-Chlorophenyl-cyclobutanecarboxylic acid; 1-Carboxy-3-(4-chlorophenyl)cyclobutane; Cyclobutanecarboxylic acid, 3-(4-chlorophenyl)-; (3-(4-Chlorophenyl)cyclobutyl)carboxylic acid; 1384429-60-0 (CAS)
EINECS	Contact for details

Quality Control

Our 3-(4-Chlorophenyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications from early-stage research to pre-clinical development under ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.