Description

H2N-Peg12-Tbu CAS NO 1383814-00-3 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a tert-butyl ester-protected carboxylic acid. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific modification of peptides, proteins, and other biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic reagent development.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to drugs, dyes, or solid surfaces via its amine-reactive terminus.
• PEGylation Reagent: Used to create PEGylated therapeutics to improve pharmacokinetics, solubility, and stability of active pharmaceutical ingredients (APIs).
• Crosslinking Agent: In the synthesis of hydrogels, polymer networks, and biomaterial scaffolds for tissue engineering.
• Diagnostic Probe Synthesis: For attaching targeting ligands to imaging agents or fluorescent labels in diagnostic assays.
• ADC (Antibody-Drug Conjugate) Development: As a key component in the linker-payload construct for targeted cancer therapies.
• Surface Functionalization: To introduce amine-reactive groups onto nanoparticles, chips, or other substrates for subsequent biomolecule immobilization.

Basic Information

Item	Detail
Product Name	H2N-Peg12-Tbu
CAS No.	1383814-00-3
Molecular Formula	C31H63NO14
Molecular Weight	673.83 g/mol
Synonyms	12-Amino-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacontanoic acid 1,1-dimethylethyl ester; Amino-PEG12-t-butyl ester; tert-Butyl (1-amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-38-oate); H2N-PEG12-COOtBu; Amine-PEG12-acid t-butyl ester; 1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-38-oic acid tert-butyl ester; NH2-PEG12-tBu ester
EINECS	Contact for details

Quality Control

Our H2N-Peg12-Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and cGMP-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Verification (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.