Description

4-Chloro-2-Methyl-5-(Trifluoromethyl)Aniline is a high-value, multi-functional aromatic amine building block distinguished by its unique trifluoromethyl and chloro substituents. This compound is critical for synthesizing advanced molecules where the introduction of fluorine atoms and halogenated aniline motifs can dramatically alter physical, chemical, and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a core building block for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Used in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Industry: Acts as a precursor for specialized azo dyes and pigments requiring halogenated aniline components for specific color fastness and properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl and aniline derivatives.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on understanding the influence of fluorine atoms on molecular reactivity and bioactivity.

Basic Information

Product Name	4-Chloro-2-Methyl-5-(Trifluoromethyl)Aniline
CAS No.	1379346-32-3
Molecular Formula	C8H7ClF3N
Molecular Weight	209.60 g/mol
Synonyms	2-Methyl-4-chloro-5-(trifluoromethyl)aniline; 5-(Trifluoromethyl)-4-chloro-2-methylaniline; 4-Chloro-2-methyl-5-(trifluoromethyl)benzenamine; 2-Methyl-4-chloro-α,α,α-trifluoro-m-toluidine; Benzenamine, 4-chloro-2-methyl-5-(trifluoromethyl)-; 4-Chloro-2-methyl-α,α,α-trifluoro-m-toluidine
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-2-Methyl-5-(Trifluoromethyl)Aniline adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure consistency and meet the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This amine derivative should be kept under an inert atmosphere if long-term storage is required to minimize potential oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.