Description

4-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity and physicochemical properties imparted by the difluoromethyl group, which is a key motif in modern medicinal and agrochemical design. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a fluorinated core structure for synthesizing specialty chemicals used in electronic displays and organic light-emitting diodes.
• Fluorinated Surfactant & Polymer Research: Acts as a monomer or modifier in the development of fluoropolymers and specialty surfactants with unique surface properties.
• Chemical Biology Probe Development: Utilized in the creation of isotopically labeled or tagged compounds for studying biochemical pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in client-specific projects requiring fluorinated cyclohexane scaffolds.

Basic Information

Product Name	4-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid
CAS No.	1378852-94-8
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	4-(Difluoromethyl)cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 4-(difluoromethyl)-; 4-(Difluoromethyl)-1-cyclohexanecarboxylic acid; 1-Carboxy-4-(difluoromethyl)cyclohexane; 4-Difluoromethylcyclohexanecarboxylic acid; trans/cis-4-(Difluoromethyl)cyclohexane-1-carboxylic acid (mixture); DFM-CHCA
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity, isomeric ratio, and impurity profiles as determined by HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Ratio (cis/trans)	Reported on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.