Description

5,5,5-Trifluoropent-3-Yn-2-One is a high-value fluorinated alkyne building block, distinguished by its trifluoromethyl group and terminal alkyne functionality. This unique structure makes it a critical intermediate for introducing fluorine atoms into target molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with improved efficacy and environmental profile.
• Material Science: Serves as a monomer or cross-linker for creating specialty polymers with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: A precursor for fluorinated components in electronic display and lighting technologies.
• Click Chemistry: The alkyne group enables efficient Huisgen cycloaddition reactions for bioconjugation and polymer functionalization.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of Positron Emission Tomography (PET) imaging tracers.

Basic Information

Product Name	5,5,5-Trifluoropent-3-Yn-2-One
CAS No.	1378522-73-6
Molecular Formula	C5H3F3O
Molecular Weight	136.07 g/mol
Synonyms	1,1,1-Trifluoro-4-pentyn-2-one; 5,5,5-Trifluoropent-3-yn-2-one; 4-Pentyn-2-one, 1,1,1-trifluoro-; Trifluoromethyl alkynyl ketone; 3-Butyn-2-one, 1,1,1-trifluoro- (rearranged IUPAC); TFPO building block; Fluorinated alkyne ketone
EINECS	Contact for details

Quality Control

Our 5,5,5-Trifluoropent-3-Yn-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, GC/HPLC, and Karl Fischer titration, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat, sparks, and open flame. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.