Description

3-(2-Bromoacetyl)-10,11-Dihydro-5H-Benzo[D]Naphtho[2,3-B]Pyran-8(9H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused-ring structure and reactive bromoacetyl functional group. This compound is of critical importance for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily required by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking to build sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates targeting neurological disorders and cancer.
• Organic Synthesis Reagent: Used in complex multi-step organic syntheses, including cyclization and coupling reactions, due to its reactive bromoacetyl moiety.
• Research & Development: Essential for medicinal chemistry research in academic and industrial settings for structure-activity relationship (SAR) studies.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	3-(2-Bromoacetyl)-10,11-Dihydro-5H-Benzo[D]Naphtho[2,3-B]Pyran-8(9H)-One
CAS No.	1378390-29-4
Molecular Formula	C21H15BrO3
Molecular Weight	395.25 g/mol
Synonyms	3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[b,f]oxepin-8(9H)-one; 10,11-Dihydro-3-(2-bromoacetyl)-5H-dibenzo[b,f]oxepin-8(9H)-one; 8(9H)-One, 3-(2-bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-; Dibenzo[b,f]oxepin-8(9H)-one, 10,11-dihydro-3-(2-bromoacetyl)-; 1378390-29-4
EINECS	Contact for details

Quality Control

Our production of 3-(2-Bromoacetyl)-10,11-Dihydro-5H-Benzo[D]Naphtho[2,3-B]Pyran-8(9H)-One adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality systems are designed to support development through to commercial scale, meeting the exacting standards required for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.