Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde Oxime is a high-value, functionalized boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in the unique combination of a protected boronic acid group and an oxime functional group, enabling precise chemical transformations in advanced organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules via Suzuki-Miyaura cross-coupling and other palladium-catalyzed reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic boronate motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs, where the boronate group facilitates precise molecular assembly.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors, leveraging the oxime ligation chemistry.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures, which are ubiquitous scaffolds in medicinal chemistry.
• Ligand Synthesis: Serves as a precursor for synthesizing sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde Oxime
CAS No.	1374215-74-3
Molecular Formula	C13H18BNO3
Molecular Weight	247.10 g/mol
Synonyms	4-Formylphenylboronic Acid Pinacol Ester Oxime; (4-(((E)-Hydroxyimino)methyl)phenyl)boronic Acid Pinacol Ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarboxaldehyde Oxime; 4-(Pinacolatoboron)benzaldehyde Oxime; Benzaldehyde, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, Oxime; 4-Borono-Benzaldehyde Oxime Pinacol Ester; 4-(BPin)-Benzaldehyde Oxime
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde Oxime is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your R&D and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.