Description

trans-2-Amino-3,3-Dimethylcyclobutanecarboxylic Acid CAS NO 1373621-71-6 is a high-purity, non-proteinogenic amino acid derivative featuring a rigid cyclobutane ring structure. This compound is of significant value as a key chiral building block and intermediate in advanced pharmaceutical synthesis and medicinal chemistry research. It is primarily sought after by R&D chemists and process development scientists working on novel drug candidates, particularly in the areas of peptide mimetics and constrained analogs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Ligand & Catalyst Development: Potential precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme mechanisms or as a substrate analog.
• Academic & Industrial R&D: Fundamental building block for synthetic organic chemistry research in academic and corporate laboratories.

Basic Information

Product Name	trans-2-Amino-3,3-Dimethylcyclobutanecarboxylic Acid
CAS No.	1373621-71-6
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(1R,2S)-2-Amino-3,3-dimethylcyclobutanecarboxylic acid; (1S,2R)-2-Amino-3,3-dimethylcyclobutanecarboxylic acid; trans-2-Amino-3,3-dimethyl-1-cyclobutanecarboxylic acid; 2-Amino-3,3-dimethylcyclobutanecarboxylic acid, trans-; 3,3-Dimethylcyclobutanecarboxylic acid, 2-amino-, trans-; 2-ADCB; DM-CBAA; Cyclobutane amino acid derivative
EINECS	Contact for details

Quality Control

Our trans-2-Amino-3,3-Dimethylcyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.