Description

2-Borono-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester is a high-value, protected boronic acid ester derivative that serves as a critical synthetic intermediate in modern organic and medicinal chemistry. Its primary value lies in enabling the construction of complex heterocyclic scaffolds via cross-coupling reactions, a cornerstone of pharmaceutical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, enabling the modular assembly of complex molecules.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds containing the pyrrolopyridine core.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, and insecticides that incorporate advanced heterocyclic structures.
• Material Science Precursor: Potential monomer or functionalizing agent for creating organic electronic materials or metal-organic frameworks (MOFs) with specific binding properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process scale-up for client projects.

Basic Information

Product Name	2-Borono-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester
CAS No.	1373273-49-4
Molecular Formula	C14H17BN2O4
Molecular Weight	288.11 g/mol
Synonyms	1-(tert-Butyl) 2-borono-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; tert-Butyl 2-boronopyrrolo[2,3-b]pyridine-1-carboxylate; 1-Boc-2-boronopyrrolo[2,3-b]pyridine; 2-Boronopyrrolo[2,3-b]pyridine-1-carboxylic Acid tert-Butyl Ester; 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic Acid, 2-borono-, 1-(1,1-dimethylethyl) ester; 2-Boronopyrrolo[2,3-b]pyridine, N-Boc protected; 7-Azaindole-2-boronic acid tert-butyl ester (N-Boc protected); CAS 1373273-49-4
EINECS	Contact for details

Quality Control

Our 2-Borono-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material produced under GMP-like conditions for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.