Description

(R)-Bi(tert-Butyl)(6-Chloro-4-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridazin-3-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and complex heterocyclic structure. This compound is of critical importance for the research and development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily needed by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of targeted, small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potent and selective kinase inhibitors for oncology and inflammatory disease research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of candidate drug molecules during preclinical and process development stages.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, scalable production of target active ingredients under cGMP conditions.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-Bi(tert-Butyl)(6-Chloro-4-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridazin-3-Yl)Carbamate
CAS No.	1370651-32-3
Molecular Formula	C21H23Cl3FN3O3
Molecular Weight	490.78 g/mol
Synonyms	(R)-Di-tert-butyl (6-chloro-4-((1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridazin-3-yl)carbamate; (R)-Boc2-6-Chloro-4-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridazine-3-carbamate; tert-Butyl (6-chloro-4-{[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridazin-3-yl)carbamate; (R)-N,N-Di-tert-butyloxycarbonyl-6-chloro-4-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridazin-3-amine; CAS 1370651-32-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.