Description

2-Bromo-1-(4,4-Difluorocyclohexyl)Ethanone is a high-value, specialized organic building block featuring a reactive bromoacetyl group attached to a difluorinated cyclohexyl scaffold. This compound matters for its unique combination of a reactive electrophilic center and a lipophilic, metabolically stable fluorinated ring system, making it a critical intermediate in modern synthetic chemistry. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research organizations for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, GPCR modulators, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the difluorocyclohexyl moiety can enhance bioavailability and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating activity-based probes (ABPs) or affinity tags due to its reactive bromo ketone group, which can alkylate nucleophilic residues.
• Material Science Precursor: Potential intermediate for synthesizing specialty monomers or ligands used in advanced polymers, coatings, or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Bromo-1-(4,4-Difluorocyclohexyl)Ethanone
CAS No.	1370601-11-8
Molecular Formula	C8H11BrF2O
Molecular Weight	241.08 g/mol
Synonyms	2-Bromo-1-(4,4-difluorocyclohexyl)ethan-1-one; 2-Bromo-4,4-difluorocyclohexyl methyl ketone; 4,4-Difluorocyclohexyl Bromomethyl Ketone; α-Bromo-4,4-difluorocyclohexyl methyl ketone; 2-Bromo-1-(4,4-difluorocyclohexyl)ethanone; Bromo(4,4-difluorocyclohexyl)methyl ketone; (4,4-Difluorocyclohexyl)-2-bromoethanone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4,4-Difluorocyclohexyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and incompatible organic solvents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.