Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Methylselanyl)Propanoic Acid is a specialized, high-purity amino acid derivative designed for advanced research and pharmaceutical development. This compound matters as a key building block in solid-phase peptide synthesis (SPPS), where its unique selenomethyl side chain enables the introduction of selenium for structural studies, redox-active peptides, or selenoprotein mimics. It is essential for researchers and manufacturers in medicinal chemistry, biochemistry, and proteomics who require precise, protected amino acid analogs to create novel peptide-based therapeutics and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical Fmoc-protected building block for the automated synthesis of complex peptides containing selenocysteine analogs.
• Medicinal Chemistry Research: Used in the design and development of novel peptide drugs, where selenium incorporation can modulate activity, stability, and redox properties.
• Selenoprotein Studies: Enables the site-specific introduction of selenium into peptide sequences to model and study the function of natural selenoproteins.
• Bioconjugation & Probe Development: The reactive selenomethyl group can be utilized for selective chemical modifications and the creation of labeled peptides for diagnostic or imaging applications.
• Chemical Biology Tool Development: Serves as a precursor for synthesizing specialized amino acids used to investigate protein structure, folding, and enzyme mechanisms.
• Pharmaceutical Intermediate: Acts as a key chiral intermediate in the multi-step synthesis of more complex bioactive molecules targeting various therapeutic areas.

Basic Information

Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Methylselanyl)Propanoic Acid
CAS No.	1369532-59-1
Molecular Formula	C19H19NO4Se
Molecular Weight	412.32 g/mol
Synonyms	Fmoc-Sec(Me)-OH; Fmoc-Selenomethyl-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(methylseleno)-L-alanine; (2R)-2-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)-3-(methylselanyl)propanoic acid; Fmoc-L-Sec(Me)-OH; Fmoc-S-methylselenocysteine; Fmoc-protected methylselenocysteine; L-Selenomethylcysteine Fmoc derivative
EINECS	Contact for details

Quality Control

Every batch of (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Methylselanyl)Propanoic Acid is produced and tested under strict quality management systems to ensure the high purity and consistency required for sensitive research and development applications. Our products undergo rigorous quality testing, including chiral purity verification and impurity profiling, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific rotation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is light-sensitive (store away from light) and should be allowed to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.