Description

(1E)-3-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-N'-Hydroxypropanimidamide is a high-purity chemical building block of significant interest in advanced organic synthesis. This compound, with CAS number 1365988-65-3, is valued for its role as a key intermediate in the development of pharmacologically active molecules, particularly those targeting specific enzymatic pathways. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry and drug discovery programs.

Application

This specialized intermediate serves critical functions in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly hydroxamic acid derivatives and HDAC (Histone Deacetylase) inhibitors.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecular scaffolds in lead optimization and structure-activity relationship (SAR) studies.
• Bioconjugation & Probe Development: Employed in the creation of chemical probes and affinity labels for studying biological targets and mechanisms.
• Organic Synthesis: Serves as a versatile reagent for introducing the N-hydroxyamidine or phthalimide-protected functional groups into target molecules.

Basic Information

Product Name	(1E)-3-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-N'-Hydroxypropanimidamide
CAS No.	1365988-65-3
Molecular Formula	C11H11N3O3
Molecular Weight	233.22 g/mol
Synonyms	N-Hydroxy-3-(1,3-dioxoisoindolin-2-yl)propanimidamide; 2-[(1E)-3-(Hydroxyamino)-3-iminopropyl]isoindoline-1,3-dione; (E)-N'-Hydroxy-3-(1,3-dioxoisoindolin-2-yl)propanimidamide; 3-(1,3-Dioxoisoindolin-2-yl)-N'-hydroxypropanimidamide; 1365988-65-3; Propanimidamide, 3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-N'-hydroxy-, (1E)-
EINECS	Contact for details

Quality Control

Our (1E)-3-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-Yl)-N'-Hydroxypropanimidamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.