Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{[(4-Methylphenyl)Methyl]Selanyl}Propanoic Acid is a specialized, high-purity amino acid derivative containing a selenium-protected side chain, primarily used as a critical building block in advanced peptide synthesis and pharmaceutical research. Its core value lies in enabling the precise introduction of selenocysteine analogs and other selenium-containing motifs into complex molecules, which is essential for studying protein structure, function, and for developing novel therapeutic agents. This compound is indispensable for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced organic synthesis who require reliable, high-quality intermediates for constructing bioactive peptides and investigating redox-active biological systems.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the controlled incorporation of selenium-modified amino acids into peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of selenocysteine-containing drug candidates and investigational new drugs (INDs).
• Bioconjugation and Probe Development: Used to create selenium-labeled peptides and proteins for biochemical assays, imaging studies, and structural biology.
• Research into Selenoproteins: Enables the study of natural selenoproteins and the engineering of artificial selenoenzymes by providing a stable, protected selenocysteine analog.
• Organoselenium Chemistry: Acts as a versatile chiral synthon for exploring new reactions and catalytic cycles in organoselenium chemistry.
• High-Value Fine Chemical Production: Employed in the multi-step synthesis of complex, high-purity active pharmaceutical ingredients (APIs) and specialty chemicals.

Basic Information

Item	Details
Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{[(4-Methylphenyl)Methyl]Selanyl}Propanoic Acid
CAS No.	1365284-49-6
Molecular Formula	C26H25NO4Se
Molecular Weight	486.44 g/mol
Synonyms	Fmoc-Sec(Mob)-OH; Fmoc-Selenocysteine(Mob)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(4-methylbenzyl)selanyl]-L-alanine; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[(4-methylphenyl)methaneselanyl]propanoic acid; Fmoc-L-Sec(Mob)-OH; Fmoc-Sec(p-Me-Bzl)-OH; N-α-Fmoc-N-α-[(4-methylbenzyl)seleno]-L-cysteine
EINECS	Contact for details

Quality Control

Our (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-{[(4-Methylphenyl)Methyl]Selanyl}Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with full analytical data are provided for every shipment, ensuring traceability, consistency, and compliance with your research and production protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is moisture-sensitive; ensure the container is sealed in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.