Description

Potassium (1-Boc-4-Piperidinyloxy)Methyltrifluoroborate is a high-value organotrifluoroborate salt, a crucial building block in modern synthetic chemistry. Its primary value lies in its exceptional stability and reactivity, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions compared to traditional boronic acids. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the precise introduction of the (1-Boc-4-piperidinyloxy)methyl moiety via palladium-catalyzed cross-coupling, critical in developing central nervous system (CNS) and oncology drug candidates.
• Agrochemical Research & Development: Used to create novel heterocyclic compounds and complex molecules for next-generation herbicides, fungicides, and insecticides.
• Material Science Precursor: Serves as a specialized monomer or building block for synthesizing advanced polymers and organic electronic materials.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for structure-activity relationship (SAR) studies due to its air- and moisture-stable nature.
• Process Chemistry & Scale-up: Provides a reliable and scalable route for the late-stage functionalization of complex molecules in API manufacturing under mild conditions.
• Academic & Industrial Research: A fundamental tool for methodological development in organometallic chemistry and new catalytic cross-coupling protocols.

Basic Information

Product Name	Potassium (1-Boc-4-Piperidinyloxy)Methyltrifluoroborate
CAS No.	1364936-24-2
Molecular Formula	C12H21BF3KNO4
Molecular Weight	350.12 g/mol
Synonyms	Potassium (1-tert-Butoxycarbonyl-4-piperidinyloxy)methyltrifluoroborate; Potassium Trifluoro[(1-tert-Butoxycarbonyl-4-piperidinyloxy)methyl]borate; (1-Boc-4-Piperidinyloxy)Methyltrifluoroborate Potassium Salt; 1-Boc-4-[(Potassium Trifluoroboratomethyl)oxy]piperidine; 4-[(Potassium Trifluoroboratomethyl)oxy]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; KBpin-O-Pip-Boc (common abbreviation); Boc-Pip-O-CH2-BF3K
EINECS	Contact for details

Quality Control

Our Potassium (1-Boc-4-Piperidinyloxy)Methyltrifluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 13C), HPLC for purity assessment, and KF titration for moisture content, to ensure it meets the high standards required for sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage and when opening the container to prevent degradation. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
11B NMR Purity	≥ 97%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.