Description

Methyl 4-Aminotetrahydro-2H-Thiopyran-4-Carboxylate 1,1-Dioxide Hcl CAS NO 1363992-79-3 is a high-purity, advanced pharmaceutical intermediate characterized by its sulfone and ester functional groups. This compound is of significant value for its role as a key building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily required by research and development chemists and process development scientists in the pharmaceutical and biotechnology industries for creating new therapeutic candidates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry research.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of protease inhibitor molecules.
• Sulfone-Containing Molecule Synthesis: Used in organic synthesis to introduce the sulfone moiety into more complex molecular architectures.
• Peptidomimetic Research: Acts as a constrained amino acid analog for the development of peptidomimetics with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the creation of specialized chemical probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in the optimization and kilogram-scale production of target molecules for preclinical and clinical studies.

Basic Information

Product Name	Methyl 4-Aminotetrahydro-2H-Thiopyran-4-Carboxylate 1,1-Dioxide Hcl
CAS No.	1363992-79-3
Molecular Formula	C7H14ClNO4S
Molecular Weight	243.71 g/mol
Synonyms	Methyl 4-amino-1,1-dioxo-1λ⁶-thiane-4-carboxylate hydrochloride; 4-(Methoxycarbonyl)-1,1-dioxo-1λ⁶-thian-4-amine hydrochloride; 4-Amino-1,1-dioxotetrahydro-2H-thiopyran-4-carboxylic acid methyl ester hydrochloride; Methyl 4-aminotetrahydro-2H-thiopyran-4-carboxylate 1,1-dioxide hydrochloride; 1,1-Dioxo-1lambda6-thiane-4-carboxylic acid, 4-amino-, methyl ester, hydrochloride; 4-Amino-tetrahydro-2H-thiopyran-4-carboxylic acid methyl ester S,S-dioxide hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 4-Aminotetrahydro-2H-Thiopyran-4-Carboxylate 1,1-Dioxide Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.