Description

cis-Ethyl 3-(Boc-Amino)-Tetrahydro-2H-Pyran-4-Carboxylate CAS NO 1363404-85-6 is a high-purity, protected amino acid derivative featuring a tetrahydro-2H-pyran (THP) scaffold and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, cyclic structures into peptide backbones to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry & SAR Studies: Serves as a versatile scaffold for structure-activity relationship (SAR) exploration and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for target molecules under current Good Manufacturing Practice (cGMP) standards.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to construct molecules with defined three-dimensional configurations.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function, protein-protein interactions, and biological pathways.

Basic Information

Product Name	cis-Ethyl 3-(Boc-Amino)-Tetrahydro-2H-Pyran-4-Carboxylate
CAS No.	1363404-85-6
Molecular Formula	C13H23NO5
Molecular Weight	273.32 g/mol
Synonyms	Ethyl cis-3-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-4-carboxylate; 4-Carboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]tetrahydro-2H-pyran-, ethyl ester, cis-; cis-3-(Boc-amino)tetrahydro-2H-pyran-4-carboxylic acid ethyl ester; Ethyl 3-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylate (cis); Boc-3-ATHP-OEt; (3R,4S)-Ethyl 3-(Boc-amino)tetrahydro-2H-pyran-4-carboxylate; (3S,4R)-Ethyl 3-(Boc-amino)tetrahydro-2H-pyran-4-carboxylate
EINECS	Contact for details

Quality Control

Our cis-Ethyl 3-(Boc-Amino)-Tetrahydro-2H-Pyran-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.