Description

cis-(4-Amino-Tetrahydro-Furan-3-Yl)-Methanol is a high-purity chiral amino alcohol building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel pharmaceuticals, particularly for creating complex molecules with specific stereochemistry. Pharmaceutical R&D teams and fine chemical manufacturers need it for constructing active pharmaceutical ingredients (APIs), nucleoside analogs, and other bioactive compounds where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel antiviral, anticancer, and antibiotic drug candidates.
• Nucleoside/Nucleotide Chemistry: Used in the research and production of modified nucleosides for therapeutic and diagnostic applications.
• Asymmetric Synthesis: Serves as a valuable chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Protease Inhibitor Development: A building block for constructing scaffolds used in protease inhibitor research.
• Chemical Biology & Medicinal Chemistry: Employed in the design and synthesis of molecular probes and tool compounds for target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates under cGMP conditions.

Basic Information

Product Name	cis-(4-Amino-Tetrahydro-Furan-3-Yl)-Methanol
CAS No.	1354427-84-1
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	(3R,4S)-4-Amino-3-(hydroxymethyl)tetrahydrofuran; (3R,4S)-4-Amino-3-(hydroxymethyl)oxolane; cis-4-Amino-3-(hydroxymethyl)tetrahydrofuran; 3-Tetrahydrofuranylmethanol, 4-amino-, cis-; 4-Amino-3-(hydroxymethyl)tetrahydrofuran (cis isomer); Furan-3-methanol, 4-amino-tetrahydro-, cis-; Amino alcohol THF derivative
EINECS	Contact for details

Quality Control

Our cis-(4-Amino-Tetrahydro-Furan-3-Yl)-Methanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.